DNA Origami Platform for Protein Interaction Analysis
نویسندگان
چکیده
منابع مشابه
DNA Origami Reorganizes upon Interaction with Graphite: Implications for High-Resolution DNA Directed Protein Patterning
Although there is a long history of the study of the interaction of DNA with carbon surfaces, limited information exists regarding the interaction of complex DNA-based nanostructures with the important material graphite, which is closely related to graphene. In view of the capacity of DNA to direct the assembly of proteins and optical and electronic nanoparticles, the potential for combining DN...
متن کاملSingle-molecule analysis using DNA origami.
During the last two decades, scientists have developed various methods that allow the detection and manipulation of single molecules, which have also been called "in singulo" approaches. Fundamental understanding of biochemical reactions, folding of biomolecules, and the screening of drugs were achieved by using these methods. Single-molecule analysis was also performed in the field of DNA nano...
متن کاملElectron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami.
DNA provides an ideal substrate for the engineering of versatile nanostructures due to its reliable Watson-Crick base pairing and well-characterized conformation. One of the most promising applications of DNA nanostructures arises from the site-directed spatial arrangement with nanometer precision of guest components such as proteins, metal nanoparticles, and small molecules. Two-dimensional DN...
متن کاملSelf-powered Microfluidic Origami Electrochemiluminescence Biosensing Platform
1 Reagents and instruments FeCl3, anhydrous AlCl3, β-D-glucose, maltose, R-lactose and D-fructose were obtained from Beijing Chemical Reagent Company (Beijing, China), and the carbohydrate solutions were left at room temperature for 24 h before use. Al foil tape and conductive carbon ink were purchased commercially. Ru(bpy)3Cl6·6H2O, Luminol and glucose oxidase (from Aspergillus niger, GOx) wer...
متن کاملA coarse-grained model for DNA origami
Modeling tools provide a valuable support for DNA origami design. However, current solutions have limited application for conformational analysis of the designs. In this work we present a tool for a thorough study of DNA origami structure and dynamics. The tool is based on a novel coarse-grained model dedicated to geometry optimization and conformational analysis of DNA origami. We explored the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.1631